It is also possible to delivery DNA vectors directly to cells withouth the use of viruses. This involves the application of pharmaceutical methods for drug delivery to target DNA vectors to specific cells after direct administration to patients and to enhance the process by which DNA vectors are taken into cells and traffick to the nucleous were transcription can take place.
In particular, pharmaceutical experience with liposomes and other particulate drug carriers may be employed indrug delivery.
Various different approaches have been described for DNA delivery,
including the use of purified DNA administered directly into the body by intramuscular injection, the use of ballistic particles coated with DNA,
the use of cationic livids, and the use of various ligans to target DNA to specific cell types and enhance the entry of DNA into the cell. Many different methods for direct DNA delivery are currently being explored. For example, direct intramuscular injection leads to expression of genes by muscle cells and might be used to express protein such as dystrophin. Asialoglycoproteins may be coupled to DNA and used to direct DNA expression factors to liver cells to treat diseases such as familial. Hypercholesterolemia or metilmaloni asidemia. Several clinical trials are currently underway using drug delivery mehods for gene therapy of cancer and cystic fibrosis. These nonviral methods may offer agreater margin of safety and clinical acceptance than viral vectors. The progressive pharmaceuticalization of vector delivery may also result in products that can be manufactured, distributed, and administered in routine clinical practice like conventional medicines.
the use of cationic livids, and the use of various ligans to target DNA to specific cell types and enhance the entry of DNA into the cell. Many different methods for direct DNA delivery are currently being explored. For example, direct intramuscular injection leads to expression of genes by muscle cells and might be used to express protein such as dystrophin. Asialoglycoproteins may be coupled to DNA and used to direct DNA expression factors to liver cells to treat diseases such as familial. Hypercholesterolemia or metilmaloni asidemia. Several clinical trials are currently underway using drug delivery mehods for gene therapy of cancer and cystic fibrosis. These nonviral methods may offer agreater margin of safety and clinical acceptance than viral vectors. The progressive pharmaceuticalization of vector delivery may also result in products that can be manufactured, distributed, and administered in routine clinical practice like conventional medicines.
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